Sleisenger and Fordtran's gastrointestinal and liver disease : pathophysiology/diagnosis/management / [edited by] Mark Feldman, Lawrence S. Friedman, Lawrence J. Brandt.

Contributor(s): Feldman, Mark, 1947- [editor.] | Friedman, Lawrence S. (Lawrence Samuel), 1953- [editor.] | Brandt, Lawrence J [editor.]Series: Expertconsult | ClinicalKeyPublisher: Philadelphia, PA : Elsevier/Saunders, [2016]Copyright date: �2016Edition: Tenth editionDescription: 1 online resource : illustrations (chiefly color)Content type: text Media type: computer Carrier type: online resourceISBN: 9781455749898; 1455749893Other title: Gastrointestinal and liver diseaseUniform titles: Sleisenger and Fordtran's gastrointestinal and liver disease (Feldman) Subject(s): Gastrointestinal system -- Diseases | Gastrointestinal Diseases | Liver Diseases | HEALTH & FITNESS -- Diseases -- General | MEDICAL -- Clinical Medicine | MEDICAL -- Diseases | MEDICAL -- Evidence-Based Medicine | MEDICAL -- Internal Medicine | Gastrointestinal system -- DiseasesGenre/Form: Electronic books. | Electronic books. Additional physical formats: Print version:: Sleisenger and Fordtran's gastrointestinal and liver disease.DDC classification: 616.3/3 LOC classification: RC801NLM classification: WI 140 | WI 140Online resources: Click here for the e-copy
Contents:
Vol-1; Front cover; IFC_Vol. 1; Sleisenger and Fordtran's Gastrointestinal and Liver Disease; Copyright page; Dedication; Contributors; Foreword; Preface; Table of Contents; Video Contents; Abbreviation List; I Biology of the Gastrointestinal Tract; 1 Cellular Growth and Neoplasia; Chapter Outline; Mechanisms of Normal Cell Homeostasis; Cellular Proliferation; Apoptosis; Senescence; Signaling Pathways That Regulate Cellular Growth; Intestinal Tumor Development; Multistep Formation; Clonal Expansion; Cancer Stem Cells; Neoplasia-Associated Genes; Oncogenes; Peptide Growth Factor Oncogenes.
Protein Kinase-Related OncogenesSignal Transduction-Related Oncogenes (Membrane-Associated G Proteins); Nuclear Oncogenes; Tumor Suppressor Genes; Tumor Suppressor Gene Inactivation; Adenomatous Polyposis Coli Gene; TP53 Gene; SMAD4 Gene; DNA Repair Genes; Oncogenic Signaling Pathways; Noncoding RNAs; Epigenetics; Tumor Metabolism; Environmental and Microenvironmental Influences; Chemical Carcinogenesis; Dietary Factors; Microbiome; Inflammation and Cancer; Biological Features of Tumor Metastasis; Epithelial-Mesenchymal Transition; Angiogenesis and Lymphangiogenesis.
Molecular Medicine: Current and Future Approaches in Gastrointestinal OncologyMolecular Diagnostics; Genome-wide Association Studies; Whole Genome Sequencing and Exome Sequencing; Key References; References; 2 Mucosal Immunology and Inflammation*; Chapter Outline; Immune Responses in Gut-Associated Lymphoid Tissue; Controlled/Physiologic Inflammation; Oral Tolerance; Unusual Immunoglobulins of Gut-Associated Lymphoid Tissue; Physiology of Gut-Associated Lymphoid Tissue and the Intestinal Barrier; Functional Anatomy of Gut-Associated Lymphoid Tissue; Peyer's Patches and M Cells.
Intestinal Epithelial CellsAntigen Trafficking Across the Epithelium; Recognition of Pathogen-Associated Molecular Patterns by Pattern Recognition Receptors; Antigen Presentation in the Gut; Intestinal Mononuclear Cells; Intraepithelial Lymphocytes; Lamina Propria Mononuclear Cells; T Cell Differentiation; Innate Lymphoid Cells; Dendritic Cells; Gut-Associated Lymphoid Tissue-Relevant Chemokines; Key References; References; 3 The Enteric Microbiota; Chapter Outline; Life without Microbes; Primer on Terminology; Methodologies Used to Study the Microbiota; Next-Generation Sequencing; HITChip.
MetagenomicsCharacteristics of the Human Gastrointestinal Microbiota; Host-Microbe Spatial Relationships; Host-Microbe Age-Sensitive Relationships; Microbe-Microbe Signaling; Language of Host-Microbe Dialogue; Microbes, Immunity, and Metabolic Health; Microbiota Composition and Disease Associations; Microbes and Drugs; Therapeutic Manipulation of the Microbiota; Intestinal Virome; Future Directions; Key References; References; 4 Gastrointestinal Hormones and Neurotransmitters; Chapter Outline; Hormones and Neurotransmitters; Definitions; Modes of Transmitter Release; Endocrine; Paracrine.
Summary: Now in its 10th edition, Sleisenger and Fordtran's Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments-with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos.
List(s) this item appears in: COM - Gastroenterology
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Includes bibliographical references.

Now in its 10th edition, Sleisenger and Fordtran's Gastrointestinal and Liver Disease remains your indispensable source for definitive, state-of-the-art answers on every aspect of gastroenterology and hepatology. Overcome your most complex clinical challenges and make optimal use of the newest techniques, technologies, and treatments-with superb guidance from hundreds of world-renowned authorities. Meticulous updates throughout include the latest approaches and improvements in gastrointestinal and liver disease diagnosis and therapy as well as hundreds of images and 35 new procedural videos.

Online resource; title from electronic title page (ClinicalKey, viewed on February 27, 2015).

Vol-1; Front cover; IFC_Vol. 1; Sleisenger and Fordtran's Gastrointestinal and Liver Disease; Copyright page; Dedication; Contributors; Foreword; Preface; Table of Contents; Video Contents; Abbreviation List; I Biology of the Gastrointestinal Tract; 1 Cellular Growth and Neoplasia; Chapter Outline; Mechanisms of Normal Cell Homeostasis; Cellular Proliferation; Apoptosis; Senescence; Signaling Pathways That Regulate Cellular Growth; Intestinal Tumor Development; Multistep Formation; Clonal Expansion; Cancer Stem Cells; Neoplasia-Associated Genes; Oncogenes; Peptide Growth Factor Oncogenes.

Protein Kinase-Related OncogenesSignal Transduction-Related Oncogenes (Membrane-Associated G Proteins); Nuclear Oncogenes; Tumor Suppressor Genes; Tumor Suppressor Gene Inactivation; Adenomatous Polyposis Coli Gene; TP53 Gene; SMAD4 Gene; DNA Repair Genes; Oncogenic Signaling Pathways; Noncoding RNAs; Epigenetics; Tumor Metabolism; Environmental and Microenvironmental Influences; Chemical Carcinogenesis; Dietary Factors; Microbiome; Inflammation and Cancer; Biological Features of Tumor Metastasis; Epithelial-Mesenchymal Transition; Angiogenesis and Lymphangiogenesis.

Molecular Medicine: Current and Future Approaches in Gastrointestinal OncologyMolecular Diagnostics; Genome-wide Association Studies; Whole Genome Sequencing and Exome Sequencing; Key References; References; 2 Mucosal Immunology and Inflammation*; Chapter Outline; Immune Responses in Gut-Associated Lymphoid Tissue; Controlled/Physiologic Inflammation; Oral Tolerance; Unusual Immunoglobulins of Gut-Associated Lymphoid Tissue; Physiology of Gut-Associated Lymphoid Tissue and the Intestinal Barrier; Functional Anatomy of Gut-Associated Lymphoid Tissue; Peyer's Patches and M Cells.

Intestinal Epithelial CellsAntigen Trafficking Across the Epithelium; Recognition of Pathogen-Associated Molecular Patterns by Pattern Recognition Receptors; Antigen Presentation in the Gut; Intestinal Mononuclear Cells; Intraepithelial Lymphocytes; Lamina Propria Mononuclear Cells; T Cell Differentiation; Innate Lymphoid Cells; Dendritic Cells; Gut-Associated Lymphoid Tissue-Relevant Chemokines; Key References; References; 3 The Enteric Microbiota; Chapter Outline; Life without Microbes; Primer on Terminology; Methodologies Used to Study the Microbiota; Next-Generation Sequencing; HITChip.

MetagenomicsCharacteristics of the Human Gastrointestinal Microbiota; Host-Microbe Spatial Relationships; Host-Microbe Age-Sensitive Relationships; Microbe-Microbe Signaling; Language of Host-Microbe Dialogue; Microbes, Immunity, and Metabolic Health; Microbiota Composition and Disease Associations; Microbes and Drugs; Therapeutic Manipulation of the Microbiota; Intestinal Virome; Future Directions; Key References; References; 4 Gastrointestinal Hormones and Neurotransmitters; Chapter Outline; Hormones and Neurotransmitters; Definitions; Modes of Transmitter Release; Endocrine; Paracrine.

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